Azacyclonol Synthesis Essay

We report the synthesis and voltamperometric reduction of 5H-benzo[b]carbazole-6,11-dione (BCD) and its 2-R-substituted derivatives (R = −OMe, −Me, −COMe, −CF3). The electrochemical behavior of BCDs was compared to that of the 2-[(R-phenyl)amine]-1,4-naphthalenediones (PANs) previously studied. Like PANs, BCDs exhibit two reduction waves in acetonitrile. The first reduction step for the BCDs represents formation of the radical anion, and the half-wave potential (E1/2) values for this step are less negative than for that of the PANs. The second reduction wave, corresponding to the formation of dianion hydroquinone, has E1/2 values that shift to more negative potentials. A good linear Hammett−Zuman (E1/2 vs σp) relationship, similar to that for the PAN series, was also obtained for the BCDs. However, unlike the PANs, in the BCDs, the first reduction wave was more susceptible to the effect of the substituent groups than was the second wave, suggesting that the ordering of the two successive one-electron reductions in BCDs is opposite that in PANs. This is explained by the fact that the electron delocalizations in the two systems are different; in the case of BCDs there is an extra aromatic indole ring, which resists loss of its aromatic character. The electronic structures of BCD compounds were, therefore, investigated within the framework of the density functional theory, using the B3LYP hybrid functional with a double ζ split valence basis set. Our theoretical calculations show that the O1···H−N hydrogen bond, analogous to that previously described for the PAN series, is not observed in the BCDs. Laplacians of the critical points (∇2ρ) and the natural charges for the C−O bonds indicate that the first reduction wave for the BCDs corresponds to the C4−O2 carbonyl, while in the PAN series the first one-electron transfer occurred at the C1−O1 carbonyl. Natural bond orbital analysis showed that, in all the BCDs, the lowest unoccupied molecular orbital (LUMO) is located at C4, whereas for the PANs, the LUMO is found at C1. The good correlation between the LUMO energy values and the E1/2 potentials (wave I) established that the first one-electron addition takes place at the LUMO. Analysis of the molecular geometry confirmed that, in both series of compounds, the effect of the substituent groups is mainly on the C4−O2 carbonyl. These results explain the fact that reduction of the C4−O2 carbonyl (voltammetric wave II in the PANs and voltammetric wave I in the BCDs) is more susceptible to the effect of the substituent groups than is reduction of the C1−O1 carbonyl (wave I in the PANs and wave II in the BCDs).

Azacyclonol (trade names Ataractan, Calmeran, Frenoton, Frenquel, Psychosan), also known as γ-pipradrol, is a drug which is an ataractive; an agent which diminishes hallucinations in psychotic individuals.[1][2] It has also been called a tranquilizer and antipsychotic, though these definitions are not accurate as it does not actually possess such properties. Despite being a positional isomer of pipradrol, it is not a psychostimulant, and instead has mild depressant effects.[1][3]

The drug was introduced in Europe in the mid-1950s for the treatment of schizophrenia likely because it was found to attenuate the subjective psychedelic effects of LSD and mescaline in humans.[1][4] However, due to poor and mixed clinical effectiveness[4] it never gained widespread acceptance and was eventually discontinued.

Azacyclonol is also known as diphenylmethanolpiperidine and is the parent structure of the antihistaminesfexofenadine and terfenadine. Terfenadine produces azacyclonol as a major active metabolite.[5]

It is made by the organometallic addition of 4-bromopyridine to benzophenone, followed by catalytic hydrogenation of the pyridine heteroaromatic ring system to the corresponding piperidine.[6]


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